milk thistle depression

Studies have shown improvements in liver function in people with liver diseases who have taken a milk thistle supplement, suggesting it could help reduce liver inflammation and liver damage (9). There is no standardized dosage or recommended intake for milk thistle tea, but it's generally considered safe if consumed in moderation. Advanced milk thistle extract contains phytonutrients that fight oxidative stress and support liver health. The following list is not exhaustive. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. Please enable it to take advantage of the complete set of features! edeka3 Brain Fog (anxiety, depression, ADHD), lots of medications. The mention of any product, service, or therapy is not an endorsement by NCCIH. UltraThistle, the highest potency milk thistle formula, has been scientifically proven to be up to 10x more absorbable and up to 20x more effective than other standardized milk thistle formulas. Some animal studies have shown that milk thistle could be useful for reducing the side effects of cancer treatments (26, 27, 28). 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010, Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Uses of Lavender: Everything You Need to Know, 11 Popular Natural Remedies for the Common Cold, Natural Remedies for Alcohol Use Disorder, The therapeutic potential of milk thistle in diabetes, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. The terms "milk thistle" and "silymarin" are often used interchangeably. Summary Milk thistle may help lower blood sugar levels in people with type 2 diabetes, though more high-quality studies are needed. No supplement is intended to treat, cure, or prevent disease. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, Silybin and the liver: from basic research to clinical practice, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies. Some supplements are close to chemicals in efficacy like saffron (standardized extract) for depression and magnolia bark extract for anxiety. For example, in one study, researchers investigated the mood elevating effects of silymarin, a collection of phytochemicals extracted from milk thistle. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. Unexpected effects from milk thistle. Summary Milk thistle may increase breast milk production in women who are lactating, though very little research has been done to confirm its effects. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. Dosage and side effects. Receive the latest, most useful health and wellness articles, tips, special discounts on nutritional supplements and so much more. Together, you can make shared, well-informed decisions. Careers. sharing sensitive information, make sure youre on a federal Anyone have experience with Milk Thistle for OCD/Anxiety? This article will explore the uses of milk thistle and research on its potential benefits. The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA. BDNF-TrkB pathway mediates antidepressant-like roles of H. New insights into BDNF function in depression and anxiety. Some, but not all, milk thistle supplements are vegan. Milk thistle is most often used for various liver conditions, like hepatitis and fatty liver disease. Also notable is the fact that, of the 40 subjects that completed this trial, none had any adverse events or side effects with milk thistle supplementation (7). *These statements have not been evaluated by the Food and Drug Administration. Digestion and Depression . ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. One important detoxifying ingredient is milk thistle. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. Written by Cerner Multum. Milk thistle might also help prevent insulin resistance and slow the growth of cancer,. Theres some evidence that milk thistle can treat cirrhosis and chronic hepatitis, which can be caused by alcohol abuse, autoimmune disease, or viruses. Ask your doctor for advice. Questions? This flowering plant can help control blood sugar levels and enhance bone health. Talk to your doctor before taking any supplements because they might interfere with your medication. Some researchers have suggested milk thistle benefits when treating osteoporosis after menopause, and it's a commonly used supplement in the U.S. Osteoporosis is a disease caused by progressive bone loss. This content does not have an Arabic version. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. I'm looking forward to my blood results. Similar supplements to milk thistle include: Please talk with your healthcare provider about the best supplement for you. JAMA. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Large-scale, properly-designed studies are needed. They are seen in very high numbers in the brains of people with Alzheimers disease, meaning that milk thistle could potentially be used to help treat this difficult condition (21). It is possible to take too much, and liver toxicity has been observed in people with cancer taking silybin at very high doses (10 to 20 grams per day). Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. The site is secure. Silibinin significantly attenuated anxiety/depression-like behaviors caused by A1-42-treatment as shown in tail suspension test (TST), elevated plus maze (EPM) and forced swimming tests (FST). Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. These products are not intended to diagnose, treat, cure, or prevent any disease. Benefits. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. The Gale Encyclopedia of Alternative Medicine, second edition, 2004. Just amazing and timely information at your fingertips. This content does not have an English version. Milk thistle may also be used for purposes not listed in this product guide. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). Available for Android and iOS devices. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. Its regularly used as a complementary therapy by people who have liver damage due to conditions like alcoholic liver disease, non-alcoholic fatty liver disease, hepatitis and even liver cancer (1, 5, 6). 5 It was found that there was no significant difference between milk thistle and Prozac for OCD symptoms. FREE standard shipping only available in the contiguous United States. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination. There's limited evidence, though, for the role of milk thistle in bone health. Users are advised to seek the advice of their physician or other qualified health care provider with any questions you may have regarding a medical condition. These studies have also seen that milk thistle may be able to reduce the number of amyloid plaques in the brains of animals with Alzheimers disease (18, 19, 20). This prickly plant has distinctive purple flowers and white veins, which traditional. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. The therapeutic potential of milk thistle in diabetes. Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. But the evidence is limited, and some research methodologies are flawed, so its difficult to confirm these effects. Int J Mol Sci. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. Summary In animals, milk thistle has been shown to stimulate bone mineralization. Interestingly, one study found that people with acne who took 210 milligrams of silymarin per day for 8 weeks experienced a 53% decrease in acne lesions (42). #1: Milk thistle detoxifies the liver. Its been suggested that oxidative stress in the body may play a role in the development of acne (41). See additional information. People mainly use the supplement to treat liver conditions. Longe, J., ed. Its not known whether milk thistle is helpful for other conditions. However, the results from studies have been mixed, and not all have found milk thistle extract to have a beneficial effect on liver disease. If you or anyone you know is living with obsessive compulsive disorder (OCD), proclaiming the symptoms of this mood disorder as debilitating is a vast understatement. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. MILK THISTLE Reviews and User Ratings: Effectiveness, Ease of - WebMD Milk thistle may not be recommended in some situations. doi:10.1515/jbcpp-2019-0206, Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. Anticancer Drugs. Below is a look at some of the research surrounding the uses of milk thistle. Abstract Allergic asthma is a chronic inflammatory disease regulated by coordination of T-helper2 (Th2) type cytokines and inflammatory signal molecules. Milk Thistle: Generic, Uses, Side Effects, Dosages - RxList Milk Thistle | NCCIH Feng N, Luo J, Guo X. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway. Milk thistle can also be taken with cholesterol-lowering medications, like statins. This may be because people arent able to absorb enough to get a medicinal effect. The natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. Eur Endocrinol. Milk thistle may lower blood sugar levels in people with type 2 diabetes. Acne is a chronic inflammatory skin condition. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. ; Extensively studied; effective in treatment of cirrhosis, hepatitis, chemical- or . Camini FC, Costa DC. There is also concern that milk thistle might affect estrogen levels. Before taking milk thistle, talk to your doctor, pharmacist, or health care professional if you have allergies (especially to plants), have any medical conditions, or if you take other medicines or other herbal/health supplements. To ensure quality and potency in your herbal remedies, why not grow your own? Do not use different forms (tablets, liquid, extract, teas, etc) of milk thistle at the same time without medical advice. Milk Thistle: Health Benefits, Side Effects, Uses, Dose - RxList Nevertheless, pregnant women, those allergic to the Asteraceae family of plants, those with diabetes and anyone with an estrogen-sensitive condition should seek medical advice before taking it. The active ingredients in milk thistle are a group of plant compounds collectively known as silymarin (1). Huberman: "Anything that reduces 5-alpha reductase is going to reduce DHT & maintain or extend the growth phase, the anagen phase, of hair growth. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Milk Thistle: Health Benefits, Safety Information, Dosage, and More - WebMD Biomed Res Int. This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply. Get the facts on milk thistle for the liver. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments. Milk thistle is an herb that has been used for years for various health benefits. Drug class: Herbal products. The data is very limited, but one randomized controlled study found that mothers taking 420 mg of silymarin for 63 days produced 64% more milk than those taking a placebo (37). 3 Milk thistle may change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. Nanjan MJ, Betz J. Resveratrol for the management of diabetes and its downstream pathologies. Milk thistle. Not available for orders containing UltraNourish. This is especially important if you are taking any other medications for menopause or any blood thinners, such as statins. Disclaimer. There is also concern that milk thistle might affect estrogen levels. New Treatments That May Change the Game, The Latest Research on Advanced Prostate Cancer. and depression. The irony of this list of side effects being associated with drugs intended to treat anxiety, depression, and OCD is not lost on us, and ultimately begs the question, What naturally helps OCD?. The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA. Not all possible interactions are listed in this product guide. Silymarin as supportive treatment in liver diseases: a narrative review. Milk thistle Uses, Side Effects & Warnings - Drugs.com Research on milk thistle use for specific conditions shows: Milk thistle might play a role in treating certain liver conditions. It's typically recommended to avoid taking multiple supplements for the same cause at the same time. Follow all directions on the product label and package. Milk thistle is often sold as an herbal supplement. Overall, more high-quality research is needed to define the doses and clinical effects of this fascinating herb. Its herbal remedy is known as milk thistle extract. Medically reviewed by Drugs.com on Sep 29, 2022. Zargani M, Ramirez-Campillo R, Arabzadeh E. Pflugers Arch. The research on milk thistle's use in cancer patients is promising, although more research is needed to determine its benefits. Now, one substance that we know can inhibit 5-alpha reductase, although it does it pretty weakly, is saw palmetto [200-500mg/Day, 2-3 . FOIA However, the studies in humans are very limited and have yet to show a meaningful clinical effect in people (32, 33, 34, 35, 36). Fluoxetine (Prozac), for instance, clocks in at roughly $16 for 21 capsules if youre buying with the drugs.com discount card, but the side effects are often not as easy to swallow (3). Review/update the Keep in mind that supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. 2007;2007(4):CD003620. Dosing of milk thistle ranged from 150 mg twice a day to 300 mg twice a day. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. However, many of the studies are small and have methodological flaws, which makes it difficult to give firm guidance on this supplement or confirm its effects (46). Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). Milk thistle can cause: Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating Itchiness Headache If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. However, there is no solid evidence that supports these claims. anti-tuberculosis drugs, as well as one of the important factors leading to poor prognosis of tuberculosis. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. Milk thistle is a safe supplement that shows potential as a complementary therapy for various conditions, including liver disease, cancer and diabetes. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. As a result of excessive alcohol consumption, my liver was fattened and my enzymes increased. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. Other studies looking at milk thistle for cirrhosis have found conflicting results. When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . It is not known whether milk thistle passes into breast milk or if it could harm a nursing baby. . Milk thistle may have been combined with other plants or extracts in a specific preparation to treat these conditions. Some people also call it Mary thistle and holy thistle. Research Breakdown on Milk Thistle - Examine Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. It is primarily considered a cleansing agent and used to block or flush toxins from the body. This publication is not copyrighted and is in the public domain. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in people with type 2 diabetes. https://www.nccih.nih.gov/health/milk-thistle. IBM Micromedex. While milk thistle has been traditionally used in pregnant and breastfeeding women, its safety is unknown. Do not use extra milk thistle to make up the missed dose. Epub 2013 Oct 14. . However, one area of milk thistle research focuses on how it affects bone marrow, which contributes to overall bone health but also has implications in treating diseases like multiple myeloma, a type of blood cancer. Below is a short list of 4 widely available and very affordable herbs with some serious natural health benefits for OCD sufferers: Before introducing milk thistle into your diet, new supplements or any other herbs for OCD for that matter you should consult your physician. Milk Thistle is used to treat alcoholic liver disease, gallbladder problems, hepatic cirrhosis, hepatitis (chronic), hepatotoxicity (chemical/drug-induced), jaundice, pleurisy, prostate cancer, and spleen diseases, and used as an appetite stimulant.. While more research into milk thistle, silymarin, and its effectiveness in treating OCD is definitely needed, there is a wealth of information supporting the other health benefits of milk thistle for a host of ailments: Liver Health It is believed that milk thistle and silymarin bolsters liver function by prohibiting toxic substances from binding to liver cells (6). Endo-Lysosomal and Autophagy Pathway and Ubiquitin-Proteasome System in Mood Disorders: A Review Article. Milk thistle's main active component is silymarin which works by normalizing levels of both serotonin and dopamine. The study researchers hypothesize that milk thistle's antioxidant qualities make it a good candidate for treating conditions like cancer, hepatitis, NAFLD, diabetes, depression, and heart disease. Why does zinc cause anxiety and depression for some people? However, there is no solid evidence that supports these claims. Milk thistle ( Silybum marianum) is an herbal remedy used mainly to protect and detoxify the liver. You may opt-out of email communications at any time by clicking on National Center for Complementary and Integrative Health. Neuroprotective potential of silymarin against CNS disorders: insight into the pathways and molecular mechanisms of action. include protected health information. https://www.wolterskluwercdi.com/facts-comparisons-online/. Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes.

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